PDB-ID	Chain	Mutation	Activity-Experimental	Activity-Predicted
3AT1	A	P268A	unaffected	unaffected
1COM	K	R90A	affected	unaffected
1COM	K	R90G	affected	unaffected
1COM	K	R90K	affected	affected
1CDG	A	Y89G	unaffected	unaffected
1CDG	A	Y89D	unaffected	unaffected
1IWI	A	T252I	unaffected	unaffected
1DE8	B	M271A	unaffected	unaffected
1DE8	B	R177A	unaffected	unaffected
1DPG	A	D177N	unaffected	unaffected
1DPG	A	S215C	unaffected	unaffected
1EH9	A	C298V	unaffected	unaffected
1CL6	A	S286V	unaffected	unaffected
1CL6	A	S286T	unaffected	unaffected
1CL6	A	D393L	affected	affected
1CL6	A	D393V	affected	affected
1WAB	A	R22K	affected	unaffected
1WAB	A	L26A	unaffected	unaffected
1WAB	A	R29K	unaffected	unaffected
1IPD	A	A172V	unaffected	unaffected
1IPD	A	A172I	unaffected	unaffected
1IPD	A	A172L	unaffected	unaffected
1IPD	A	A172F	unaffected	unaffected
1IPD	A	A172G	unaffected	affected
1IPD	A	A172D	unaffected	affected
1IPD	A	A172E	unaffected	affected
1E6Z	A	E144Q	affected	unaffected
1E6Z	A	S93A	unaffected	unaffected
1E6Z	A	Y10F	unaffected	unaffected
1E1A	A	W244Y	unaffected	unaffected
1E1A	A	W244H	unaffected	unaffected
1E1A	A	W244F	unaffected	unaffected
1E1A	A	W244L	unaffected	unaffected
1E1A	A	E37Q	unaffected	unaffected
1E1A	A	S271A	unaffected	unaffected
1E1A	A	E21Q	affected	unaffected
1E1A	A	D229N	affected	unaffected
1TC2	A	D115E	unaffected	affected
1TC2	A	D115Q	unaffected	affected
1TC2	A	D115N	unaffected	unaffected
1TC2	A	D115C	unaffected	unaffected
1TC2	A	D115A	unaffected	unaffected
1TC2	A	D115V	unaffected	affected
1TC2	A	D115L	unaffected	affected
1IR8	A	M12L	unaffected	unaffected
1IR8	A	M12F	unaffected	unaffected
1M8F	A	H19A	unaffected	unaffected
1K7G	A	M226A	unaffected	unaffected
1K7G	A	M226I	unaffected	unaffected
1K7G	A	M226L	unaffected	unaffected
1K7G	A	E189A	unaffected	unaffected
1K7G	A	Y228F	unaffected	unaffected
1ONR	A	D17A	unaffected	unaffected
1ONR	A	D17N	unaffected	unaffected
1ONR	A	N35A	unaffected	unaffected
1ONR	A	E96A	unaffected	unaffected
1ONR	A	E96Q	unaffected	unaffected
1ONR	A	T156A	unaffected	unaffected
1ONR	A	S176A	unaffected	unaffected
1ONR	A	R300A	unaffected	unaffected
1ONR	A	R300E	unaffected	unaffected
1JR2	A	T62A	unaffected	unaffected
1JR2	A	S63A	unaffected	unaffected
1JR2	A	R65A	unaffected	unaffected
1JR2	A	E127A	unaffected	unaffected
1JR2	A	Y168A	unaffected	unaffected
1JR2	A	S197A	unaffected	unaffected
1JR2	A	K220A	unaffected	unaffected
1JR2	A	T227A	unaffected	unaffected
1E6Z	A	D140N	unaffected	unaffected
1D2K	A	D167N	unaffected	unaffected
1D2K	A	E171Q	affected	unaffected
1L38	A	A82P	unaffected	unaffected
1L38	A	G77A	unaffected	unaffected
1L38	A	G156D	unaffected	unaffected
1L38	A	P86A	unaffected	unaffected
1L38	A	P86R	affected	unaffected
1L38	A	P86D	unaffected	unaffected
1L38	A	P86C	unaffected	unaffected
1L38	A	P86H	unaffected	unaffected
1L38	A	P86S	unaffected	unaffected
1L38	A	K60P	unaffected	unaffected
1L38	A	A93P	unaffected	unaffected
1L38	A	A74P	affected	affected
1L38	A	V111F	unaffected	affected
1L38	A	V111I	unaffected	affected
1L38	A	T26S	unaffected	unaffected
1L38	A	T151S	unaffected	unaffected
1L38	A	A93T	unaffected	unaffected
1L38	A	S117F	affected	affected
1L38	A	E11F	affected	affected
1L38	A	E11A	affected	affected
1L38	A	E11N	affected	affected
1L38	A	G30A	affected	unaffected
1L38	A	G30F	affected	affected
1L38	A	S117V	affected	unaffected
1L38	A	S117I	affected	affected
1L38	A	S117F	affected	affected
1L38	A	N132M	affected	unaffected
1L38	A	N132F	affected	affected
1L38	A	N132I	affected	unaffected
1L38	A	E11Q	affected	affected
1L38	A	E11D	affected	affected
1L38	A	E11H	affected	affected
1L38	A	D20N	affected	affected
1L38	A	D20S	affected	affected
1L38	A	D20T	affected	affected
1L38	A	D20C	unaffected	unaffected
1L38	A	D20A	affected	unaffected
1L38	A	D20V	affected	affected
1L38	A	D20E	affected	unaffected
1L38	A	T26D	affected	affected
1L38	A	T26E	affected	affected
1L38	A	T26Q	affected	affected
1L38	A	T26H	affected	affected
1L38	A	S38D	unaffected	unaffected
1L38	A	V131A	unaffected	unaffected
1L38	A	A41V	unaffected	unaffected
1L38	A	N116D	affected	unaffected
1U74	C	H175Q	unaffected	unaffected
1YAP	A	P71G	unaffected	unaffected
1YAP	A	D91P	unaffected	unaffected
1YAP	A	V110P	affected	unaffected
1YAP	A	I56T	unaffected	affected
1CTQ	A	G12V	unaffected	affected
1CTQ	A	Q61L	unaffected	unaffected
1CTQ	A	A59T	unaffected	unaffected
2END	A	E11Q	unaffected	unaffected
2END	A	H16Q	unaffected	unaffected
2END	A	Y21F	unaffected	unaffected
2END	A	K86Q	unaffected	unaffected
2END	A	D87N	unaffected	unaffected
2END	A	D87E	unaffected	unaffected
2END	A	D119N	unaffected	unaffected
2END	A	E120Q	unaffected	unaffected
2END	A	Y129F	unaffected	unaffected
2END	A	Y132W	unaffected	unaffected
2END	A	K134Q	unaffected	unaffected
1K7W	D	H178D	unaffected	unaffected
1K7W	D	H91N	unaffected	unaffected
1HMC	A	Q20A	unaffected	unaffected
1HMC	A	H9A	unaffected	unaffected
1HMC	A	H15A	affected	unaffected
1MXR	A	S211A	unaffected	unaffected
1MXR	A	S211C	unaffected	unaffected
1ANX	A	E17G	unaffected	unaffected
1ANX	A	E78Q	unaffected	unaffected
1ANX	A	E95S	unaffected	unaffected
1AKY	A	V8I	unaffected	unaffected
1AKY	A	Q48E	unaffected	unaffected
1AKY	A	T77H	unaffected	unaffected
1AKY	A	T110H	unaffected	unaffected
1AKY	A	N169D	unaffected	unaffected
1AKY	A	I213F	unaffected	unaffected
1MAC	A	E103Q	affected	unaffected
1MAC	A	D105K	affected	affected
1MAC	A	E107Q	affected	unaffected
1N75	A	A22C	unaffected	unaffected
1IO5	A	S91T	unaffected	unaffected
1IO5	A	S91V	unaffected	unaffected
1IO5	A	S91A	unaffected	unaffected
1IO5	A	T40S	unaffected	unaffected
1IO5	A	I55L	unaffected	unaffected
1IO5	A	T40I	unaffected	unaffected
1IO5	A	I55M	unaffected	unaffected
1IO5	A	S91D	unaffected	affected
1IO5	A	I55F	unaffected	unaffected
1IO5	A	S91Y	unaffected	affected
1IO5	A	I55A	unaffected	unaffected
1IO5	A	I55T	unaffected	affected
1XID	A	H54S	unaffected	unaffected
1XID	A	H54N	unaffected	unaffected
1XID	A	K183M	affected	unaffected
1CEX	A	S42A	affected	unaffected
1CEX	A	N84A	unaffected	unaffected
1CEX	A	N84L	unaffected	affected
1CEX	A	N84D	affected	affected
1CEX	A	N84W	affected	affected
1EH0	A	A245S	unaffected	unaffected
1EH0	A	A245T	unaffected	unaffected
2R1R	A	Y730F	unaffected	unaffected
2R1R	A	Y731F	unaffected	unaffected
2R1R	A	E441D	unaffected	unaffected
2R1R	A	E441Q	unaffected	unaffected
2R1R	A	E441A	unaffected	unaffected
1BQ2	A	E58Q	unaffected	unaffected
1OSI	A	A172L	unaffected	unaffected
1OSI	A	V15I	unaffected	unaffected
1OSI	A	V126M	unaffected	unaffected
1OSI	A	S92F	unaffected	unaffected
1OSI	A	I11V	unaffected	unaffected
1OSI	A	M219A	unaffected	unaffected
1FUO	A	H129N	unaffected	unaffected
1PTD	A	G83S	unaffected	unaffected
1PTD	A	K115E	unaffected	unaffected
1PTD	A	R163K	unaffected	affected
1PTD	A	W178Y	unaffected	unaffected
1PTD	A	D180S	unaffected	unaffected
1PTD	A	Y200F	unaffected	unaffected
1PTD	A	D274N	unaffected	unaffected
1MUY	A	V45N	affected	affected
1QIP	A	Q33E	unaffected	unaffected
1QIP	A	E99Q	unaffected	unaffected
4TMS	A	N229I	affected	affected
4TMS	A	N229C	affected	affected
4TMS	A	N229G	unaffected	unaffected
4TMS	A	N229W	affected	affected
4TMS	A	N229L	affected	affected
4TMS	A	N229V	affected	affected
4TMS	A	N229Y	affected	affected
4TMS	A	N229H	affected	affected
4TMS	A	N229F	affected	affected
4TMS	A	N229R	affected	affected
1EDT	A	D130N	unaffected	unaffected
1EDT	A	D130E	unaffected	unaffected
1EDT	A	D130A	unaffected	unaffected
1EDT	A	E132Q	unaffected	unaffected
1EDT	A	E132D	unaffected	unaffected
1EDT	A	E132A	affected	unaffected
2PJR	A	K37A	unaffected	unaffected
2PJR	A	T38A	unaffected	unaffected
2PJR	A	D223A	unaffected	unaffected
2PJR	A	D223N	unaffected	unaffected
2PJR	A	E224A	unaffected	unaffected
2PJR	A	R287A	unaffected	unaffected
2PJR	B	K568A	unaffected	unaffected
2PJR	B	R610A	unaffected	unaffected
1A4E	A	V111A	unaffected	unaffected
1A4E	A	F156V	unaffected	unaffected
1A4E	A	F148V	unaffected	unaffected
1A4E	A	I160A	unaffected	unaffected
1A4E	A	F159V	unaffected	unaffected
1A4E	A	F149W	unaffected	unaffected
1YDV	A	Y74C	unaffected	unaffected
1VSR	A	E25A	unaffected	unaffected
1VSR	A	D51A	affected	unaffected
1VSR	A	E84A	unaffected	unaffected
1VSR	A	E95A	unaffected	unaffected
1VSR	A	D97A	unaffected	unaffected
1VSR	A	E116A	unaffected	unaffected
1VSR	A	E123A	unaffected	unaffected
1VSR	A	E132A	unaffected	unaffected
1VSR	A	H64A	unaffected	unaffected
1VSR	A	H69A	unaffected	unaffected
1A73	A	L116A	unaffected	unaffected
1IBR	B	I178A	unaffected	unaffected
1IBR	B	I178F	unaffected	unaffected
1IBR	B	I178D	unaffected	affected