AUTO–MUTE AUTOmated server for predicting...       ...functional consequences of amino acid MUTations in protEins

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Stability Changes (ΔΔG)

Stability Changes (ΔΔG^H2O)

Stability Changes (ΔT_m)

Activity Changes

Disease Potential of Human nsSNPs

Structural Bioinformatics at
George Mason University

Questions or Comments?
mmasso@gmu.edu

Stability Changes (ΔΔG)

	PDB ID (e.g., 3PHV)	Chain (use @ if null)	Mutation (e.g., D25E)	Temperature (ºC, 0-100)	pH (-log[H+], 0-14)
Mutant #1
Mutant #2
Mutant #3
Mutant #4
Mutant #5

Note: Use D25_ to obtain predictions for all 19 substitutions at the requested position.

Select a model for making predictions (details):

Classification (sign of ΔΔG):  Regression (value of ΔΔG):

Random Forest Tree Regression (REPTree)

Support Vector Machine (SVM) SVM Regression